Extracellular fibrinogen-binding protein (Efb), a key immune evasion protein of Staphylococcus aureus and a potential therapeutic target

Due to the continued growth of antibiotic-resistant Staphylococcus aureus strains, it is necessary explore alternative targets for future therapeutic applications. For this reason, important understand staphylococcal immune evasion mechanisms with a special focus on extracellular fibrinogen-binding protein (Efb) and Efb related proteins. Therefore, was conducted literature review compile relevant information protein. It found that has three binding sites biological relevance could be used as specificity fibrinogen, platelets, complements. First, motifs also in coagulase block neutrophil αMβ2 adherence fibrinogen attract bacterial surface, forming capsule-like structures phagocytosis. Second, potent anti-thrombotic agent, probably its P-selectin capacity. blocks interaction PSGL-1 receptor, thereby impairs platelet-mediated leukocyte recruitment site vascular injury. Third, complement domain, other inhibitory proteins like Ecb, Sbi, SCIN, responsible complement-mediated response. reduces formation C3 convertase neutrophils, affect B-cells activation, maturation. have clear implication virulence mastitis, wound infection, pneumonia, infections implanted devices, contributes persistence host tissues abscess kidneys. Given infections, they are promising vaccine targets. Additionally, due effect platelets complements, can potential agent treat diseases associated thrombosis abnormal activity.